DEVELOPMENT AND PARAMETER ASSESSMENT FOR VERTICALLY ALIGNED PLATINUM WIRE APTASENSOR ARRAYS FOR IMPEDIMETRIC DETECTION OF CARDIAC BIOMARKERS
The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically an...
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Format | Patent |
Language | English |
Published |
30.12.2021
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Abstract | The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically and selectively bind to the cardiac markers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the aptamer binds to the cardiac markers of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in electrochemical impedance is indicative of the presence of the cardiac markers of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic settings. |
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AbstractList | The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically and selectively bind to the cardiac markers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the aptamer binds to the cardiac markers of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in electrochemical impedance is indicative of the presence of the cardiac markers of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic settings. |
Author | PATIL, Mitali KUMTA, Prashant N |
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RelatedCompanies | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION UNIVERSITY OF PITTSBURG - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
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Snippet | The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The... |
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Title | DEVELOPMENT AND PARAMETER ASSESSMENT FOR VERTICALLY ALIGNED PLATINUM WIRE APTASENSOR ARRAYS FOR IMPEDIMETRIC DETECTION OF CARDIAC BIOMARKERS |
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