INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE

The hemitartrate salt of a compound represented by the following structural formula:(Formula 1 Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical...

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Main Authors PETERSCHMITT, Judith, SIEGEL, Craig, WILLIS, Chris, MARSHALL, John, HARIANAWALA, Abizer, LIU, Hanlan, CHENG, Seng, COPELAND, Diane P, BHARDWAJ, Renu, SKELL, Jeffrey, PALACE, Gerard, KOCHLING, Jianmei
Format Patent
LanguageEnglish
Published 23.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The hemitartrate salt of a compound represented by the following structural formula:(Formula 1 Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
Bibliography:Application Number: US202117465994