PYRIDINIUM SALTS AS ACTIVATORS IN THE SYNTHESIS OF STEREODEFINED OLIGONUCLEOTIDES

The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling activator.

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Bibliographic Details
Main Authors Hansen, Dennis Jul, Funder, Erik Daa
Format Patent
LanguageEnglish
Published 18.11.2021
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling activator.
Bibliography:Application Number: US202117241535