Rapid Unylinker Cleavage

The present invention relates to the field of oligonucleotide synthesis using a solid support and in particular to the finding the when using a 3′ oxy-LNA nucleoside attached to the solid support of the UnyLinker types, cleavage and deprotection occurs very rapidly.

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Bibliographic Details
Main Authors Mogensen, Marianne B, Hansen, Dennis Jul, Meldgaard, Michael
Format Patent
LanguageEnglish
Published 23.09.2021
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The present invention relates to the field of oligonucleotide synthesis using a solid support and in particular to the finding the when using a 3′ oxy-LNA nucleoside attached to the solid support of the UnyLinker types, cleavage and deprotection occurs very rapidly.
Bibliography:Application Number: US201816483148