METAL OXIDES NANOPARTICLES CONJUGATED WITH NAPHTHALENE DERIVATIVES AS CONTRAST AGENTS FOR THE DETECTION OF BETA AMYLOID PLAQUES BY MAGNETIC RESONANCE IMAGES

• Main Authors: BENCOMO MARTÍNEZ, Alberto, SABLÓN CARRAZANA, Marquiza, REYES MOLINA, Israel, LEÓN CHAVIANO, Samila, SOTO MENÉNDEZ DEL VALLE, Roberto, RIVERA MARRERO, Suchitil, RODRIGUEZ-TANTY, Chryslaine, GUZMÁN RODRÍGUEZ, Andy, HERNÁNDEZ RODRÍGUEZ, Armando José, IRIARTE MESA, Claudia, RODRÍGUEZ IZQUIERDO, Julio Ricardo, PANEQUE QUEVEDO, Armando Augusto, DÍAZ GARCÍA, Alicia Marcelina, GONZÁLEZ DALMAU, Evelio
• Format: Patent
• Language: English
• Published: 23.09.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Compounds with magnetic properties are provided herein, which belong to the category of metal oxide nanoparticles, coated and conveniently functionalized, which are conjugated with naphthalene compounds related to agglomerates and β-amyloid plaques present in neurodegenerative diseases. These new nanoparticles (NPs) are used for the non-invasive detection of agglomerates and amyloid plaques using the Magnetic Resonance Imaging (MRI) technique. The nanoparticles described here cross the blood-brain barrier (BBB), without the use of any membrane-disrupting agent. Likewise, they bind with high affinity and specificity to the agglomerates and β-amyloid plaques, and are used as contrast agents in MRI for the early detection of Alzheimer's disease (AD).