TAU PET IMAGING LIGANDS

The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and c...

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Main Authors ROMBOUTS, Frederik Jan Rita, CHUPAKHIN, Vladimir, MOECHARS, Diederik Willem Elisabeth, LEENAERTS, Joseph Elisabeth, DECLERCQ, Lieven Denis Herwig, ANDRéS-GIL, José Ignacio, KOLB, Hartmuth, FIERENS, Katleen, ZHANG, Wei, BORMANS, Guy Mauritis R
Format Patent
LanguageEnglish
Published 16.09.2021
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
Bibliography:Application Number: US202117246184