NEW TREATMENT OF INTERSTITIAL LUNG DISEASES

According to the invention, there is provided a pharmaceutical composition suitable for administration to the lung, which composition comprises a plurality of amorphous nanoporous silica particles, in which one or more immunomodulatory imide drug is loaded into the pores of said particles, and where...

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Bibliographic Details
Main Authors ZHOU, Chunfang, PASZKIEWICZ, Paulina, XIA, Xin, DALSGAARD, Carl-Johan, FEILER, Adam
Format Patent
LanguageEnglish
Published 05.08.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:According to the invention, there is provided a pharmaceutical composition suitable for administration to the lung, which composition comprises a plurality of amorphous nanoporous silica particles, in which one or more immunomodulatory imide drug is loaded into the pores of said particles, and wherein the silica particles have: (a) a mass median aerodynamic diameter that is between about 0.1 μm and about 10 μm; and (b) a geometric standard deviation that is less than about 4, for use in the treatment of an interstitial lung disease by pulmonary administration. Preferred immunomodulatory imide drugs include thalidomide. Interstitial lung diseases that may be mentioned include idiopathic pulmonary fibrosis and sarcoidosis.
Bibliography:Application Number: US201917052649