A biphasic hydrogel formulation and methods of production and use thereof

• Main Authors: ISRAELSSON, Anette, STHENGEL, Elisabeth, WENNERHOLM, Johan
• Format: Patent
• Language: English
• Published: 10.06.2021
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; TREATMENT OR PROTECTION OF EYES OR EARS; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS; WORKING-UP

The present invention provides a biphasic formulation, comprising a liquid layer on the outside and an elastic hydrogel wherein the water formed on the surface of the elastic gel is physically cooling the skin by evaporating and to give a first boost of the active ingredients directly when placing on the skin of humans or animals. The biphasic formulation according to the present invention may be arranged in a hydrogel patch which creates an environment that relieves or promotes the healing process for the treatment of insect bites, sunburn, erythema, pruritus, acne, dry skin or callus. In accordance with the present invention, there is provided a biphasic hydrogel composition, comprising 6% or less PVA, physical crosslinking, glycerol as humectant and the use of water impermeable packaging to reach equilibrium of the syneresis and preserve the moisture of the gel during long-term storage.