INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS

Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant hu...

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Main Authors LI, Li, FOLTZ, Ian Nevin, BUTZ, Eric Alan, THOMSON, Christy Ann, GAVIN, Marc Alain, SEKIROV, Laura, KET, Randal Robert, DE IMUS, Cyr Clovis Chua, KANNAN, Gunasekaran, ALCORN, Dina N, LIM, Ai Ching, MANCHULENKO, Kathy, AGRAWAL, Neeraj Jagdish, XIA, Dong, BERRY, Kelly Ann
Format Patent
LanguageEnglish
Published 13.05.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
Bibliography:Application Number: US202017065395