HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety c...
Saved in:
Main Authors | , , , |
---|---|
Format | Patent |
Language | English |
Published |
22.04.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker. |
---|---|
Bibliography: | Application Number: US202017118228 |