STABLE HOT-MELT EXTRUDATE CONTAINING VALSARTAN AND SACUBITRIL
The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-cr...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
25.03.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-crystalline state. LCZ696, (pseudo)polymorphic forms thereof as well as the individual drugs, e.g. valsartan disodium and sacubitril monosodium, may be subjected to the hot-melt extrusion process. |
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Bibliography: | Application Number: US201816498909 |