STABLE HOT-MELT EXTRUDATE CONTAINING VALSARTAN AND SACUBITRIL

The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-cr...

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Bibliographic Details
Main Authors GOLLAPUDI, Rajesh Krishna Mohan, PRATHAP, Vamshi Ramana, RUCHATZ, Dieter, SCHLEHAHN, Hendrik, RALLABANDI, Bala Ramesha Chary
Format Patent
LanguageEnglish
Published 25.03.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a solid unit dosage form for oral administration (tablet or granules) containing a solid dispersion of valsartan and sacubitril in a polymeric matrix. The solid dispersion is prepared by hot-melt extrusion and may contain the active ingredients preferably in a non-crystalline state. LCZ696, (pseudo)polymorphic forms thereof as well as the individual drugs, e.g. valsartan disodium and sacubitril monosodium, may be subjected to the hot-melt extrusion process.
Bibliography:Application Number: US201816498909