SYSTEMS AND METHODS FOR MICROBIOME BASED SAMPLE CLASSIFICATION

The classification of disease status based on the stool microbiome of the subject, or other relevant DNA, is a challenging field with a lack of accurate diagnostics. Accordingly, the inventors have developed systems and methods which accurately classify the disease status of a subject using a k-mer...

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Bibliographic Details
Main Authors MANOHARAN, Arun Prasad, PROFFITT, Eric Shaun
Format Patent
LanguageEnglish
Published 25.02.2021
Subjects
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
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Summary:The classification of disease status based on the stool microbiome of the subject, or other relevant DNA, is a challenging field with a lack of accurate diagnostics. Accordingly, the inventors have developed systems and methods which accurately classify the disease status of a subject using a k-mer based algorithm for processing a subject's microbial DNA. In some examples, this includes using a logistic regression algorithm trained with L1-regularization to process DNA read derived k-mers from a subject's sample.
Bibliography:Application Number: US202016938253