METHOD AND DEVICE FOR CONSTRUCTING DIGITAL DISEASE MODULE

• Main Authors: YIN, Shu-Yi, PAN, I-Hong
• Format: Patent
• Language: English
• Published: 18.02.2021
• Subjects: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

A method for constructing a digital disease module includes: determining the relationship between changes of gene/protein expression level of a gene and a disease as a first positive-negative correlation coefficient; determining the relationship between appearance of SNP and the disease as a second positive-negative correlation coefficient; determining a gene product of the gene which is a target for disease suppression as a third positive-negative correlation coefficient; determining results of text mining for functions/activities of the gene product of the gene corresponding to the disease as a fourth positive-negative correlation coefficient; determining whether the gene is the upstream gene of the signaling transduction pathway and the relation with the disease as a fifth positive-negative correlation coefficient; adding any three or more coefficients into a first sum of coefficients; and constructing a digital disease module based on the first sum of coefficients to present disease genomic information.