MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE

• Main Authors: Yan, John, Bhat, Vinayak D, Zheng, Xiaoxia
• Format: Patent
• Language: English
• Published: 14.01.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula:wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2,-O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o-CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of:wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of:and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.