GLASS VIAL WITH LOW MIGRATION LOAD

• Main Authors: Frost, Robert, Rothhaar, Uwe, Buscke, Florence, Hladik, Bernhard
• Format: Patent
• Language: English
• Published: 24.12.2020
• Subjects: CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUSENAMELS; CHEMISTRY; GLASS; JOINING GLASS TO GLASS OR OTHER MATERIALS; MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES; METALLURGY; MINERAL OR SLAG WOOL; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS,MINERALS OR SLAGS; SURFACE TREATMENT OF GLASS

A glass vial including a boron-containing multicomponent glass includes constituents and is partially filled with a pharmaceutical ingredient formulation having a pH in a range from 5 to 9. The glass vial has a total volume of <4.5 mL, a filling level of the glass vial with the formulation is not more than 0.25, and an inner wall of the glass vial has chemical resistance to leaching-out of at least one of the constituents of the multicomponent glass. A ratio of a concentration of a leached-out constituent at a fill volume of 0.5 mL and a concentration of the leached-out constituent at a fill volume of 2 mL is not more than 3 and a ratio between a concentration of the leached-out constituent at a fill volume of 1 mL and the concentration of the leached-out constituent at a fill volume of 2 mL is not more than 2.