PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR

The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms o...

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Main Authors BIO, Matthew, FOX, Brian M, COCHRAN, Brian, FANG, Yuanqing, CAILLE, Sebastien, LUCAS, Brian S, VOUNTSOS, Filisaty, WIEDEMANN, Sean H, MCGEE, Lawrence R, WORTMAN, Sarah
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LanguageEnglish
Published 10.09.2020
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Abstract The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
AbstractList The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Author LUCAS, Brian S
CAILLE, Sebastien
COCHRAN, Brian
WIEDEMANN, Sean H
FOX, Brian M
MCGEE, Lawrence R
WORTMAN, Sarah
VOUNTSOS, Filisaty
FANG, Yuanqing
BIO, Matthew
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– fullname: VOUNTSOS, Filisaty
– fullname: WIEDEMANN, Sean H
– fullname: MCGEE, Lawrence R
– fullname: WORTMAN, Sarah
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
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MEDICAL OR VETERINARY SCIENCE
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PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
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