PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR

The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms o...

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Main Authors BIO, Matthew, FOX, Brian M, COCHRAN, Brian, FANG, Yuanqing, CAILLE, Sebastien, LUCAS, Brian S, VOUNTSOS, Filisaty, WIEDEMANN, Sean H, MCGEE, Lawrence R, WORTMAN, Sarah
Format Patent
LanguageEnglish
Published 10.09.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
AbstractList The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Author LUCAS, Brian S
CAILLE, Sebastien
COCHRAN, Brian
WIEDEMANN, Sean H
FOX, Brian M
MCGEE, Lawrence R
WORTMAN, Sarah
VOUNTSOS, Filisaty
FANG, Yuanqing
BIO, Matthew
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– fullname: VOUNTSOS, Filisaty
– fullname: WIEDEMANN, Sean H
– fullname: MCGEE, Lawrence R
– fullname: WORTMAN, Sarah
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SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
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