PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR

The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms o...

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Main Authors BIO, Matthew, FOX, Brian M, COCHRAN, Brian, FANG, Yuanqing, CAILLE, Sebastien, LUCAS, Brian S, VOUNTSOS, Filisaty, WIEDEMANN, Sean H, MCGEE, Lawrence R, WORTMAN, Sarah
Format Patent
LanguageEnglish
Published 10.09.2020
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Summary:The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Bibliography:Application Number: US201916664103