PRESERVATION OF THE NEUROMUSCULAR JUNCTION AFTER TRAUMATIC NERVE INJURY
Methods for treating nerve damage in a muscle, e.g., denervated muscle tissue (e.g., muscle damaged from traumatic injury), in a patient in need thereof featuring performing a pre-operative muscle biopsy on the denervated muscle tissue; making visible motor end plates (MEPs) in neuromuscular junctio...
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Main Author | |
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Format | Patent |
Language | English |
Published |
03.09.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Methods for treating nerve damage in a muscle, e.g., denervated muscle tissue (e.g., muscle damaged from traumatic injury), in a patient in need thereof featuring performing a pre-operative muscle biopsy on the denervated muscle tissue; making visible motor end plates (MEPs) in neuromuscular junctions (NMJs) in the biopsy; and performing a nerve transfer (e.g., partial radial nerve to axillary transfer) if (i) the MEPs shown in the biopsy persist and (ii) the MEPs shown in the biopsy retain their structures and exhibit certain morphometric properties. The nerve transfer helps regain neuromuscular function of the denervated muscle tissue. The biopsy may feature the use of two-photon microscopy. In certain embodiments, the method is performed at least 6 months after injury to the patient. |
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Bibliography: | Application Number: US202016871574 |