METHOD FOR DETERMINING THE RESPONSE OF A MALIGNANT DISEASE TO AN IMMUNOTHERAPY
A method is useful for predicting a response of a malignant disease to an immunotherapy which inhibits the PD-1 immune checkpoint signaling pathway. The method is characterized in that at least a part of an immunoregulatory gene selected from CTLA4, CD86, CD28, CD80 and/or ICOS of cells of the malig...
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Main Author | |
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Format | Patent |
Language | English |
Published |
20.08.2020
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Subjects | |
Online Access | Get full text |
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Summary: | A method is useful for predicting a response of a malignant disease to an immunotherapy which inhibits the PD-1 immune checkpoint signaling pathway. The method is characterized in that at least a part of an immunoregulatory gene selected from CTLA4, CD86, CD28, CD80 and/or ICOS of cells of the malignant disease and/or of immune cells interacting with cells of the malignant disease is subjected to a DNA methylation analysis, and the result is used to predict the response of the malignant disease to the immunotherapy. |
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Bibliography: | Application Number: US201815733039 |