Encoded Solid Phase Compound Library with Polynucleotide Based Barcoding

Provided herein are polynucleotide encoded chemical libraries comprising one or more bead members, wherein the beads comprise: a chemical moiety comprising a compound library member; a polynucleotide moiety comprising an oligonucleotide encoding the compound library member, and a barcode identifying...

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Bibliographic Details
Main Authors McEnaney, Patrick J, MacConnell, Andrew B, Kodadek, Thomas, Paegel, Brian M
Format Patent
LanguageEnglish
Published 18.06.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are polynucleotide encoded chemical libraries comprising one or more bead members, wherein the beads comprise: a chemical moiety comprising a compound library member; a polynucleotide moiety comprising an oligonucleotide encoding the compound library member, and a barcode identifying the bead; and a linking moiety, linking the chemical moiety to the polynucleotide moiety. Also provided herein are methods of making and using the polynucleotide barcoded chemical libraries, as well as kits comprising the barcoded chemical library.
Bibliography:Application Number: US201716349097