CHLOROTOXIN CONJUGATES AND METHODS OF USE THEREOF

Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate comp...

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Bibliographic Details
Main Authors Novak, Julia E, Wiss, Valorie R, Hansen, Stacey J, Nairn, Natalie, Stroud, Mark, Miller, Dennis M, Jochheim, Claudia, Byrnes-Blake, Kelly
Format Patent
LanguageEnglish
Published 18.06.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.
Bibliography:Application Number: US201916704955