INSULIN CONJUGATES

The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted...

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Main Authors BIALY, Laurent, RACKELMANN, Nils, GUESSREGEN, Stefan, KORN, Marcus Hermann, WILL, Martin, WERNER, Ulrich, BOEHME, Thomas, RIEDEL, Jens, PODESCHWA, Michael, MENDEZ PEREZ, Maria, BESENIUS, Melissa, VILLAR GAREA, Ana
Format Patent
LanguageEnglish
Published 11.06.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.
Bibliography:Application Number: US201916709208