PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
The invention relates to a process for the preparation of obeticholic acid and derivatives thereof comprising: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
28.05.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to a process for the preparation of obeticholic acid and derivatives thereof comprising:
(a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof
to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof
and
(b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof |
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Bibliography: | Application Number: US201816632304 |