PREPARATION OF CYCLIC ALLYLIC NITRO COMPOUNDS

Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method...

Full description

Saved in:
Bibliographic Details
Main Authors Collado Perez, Ana Maria, Espinos Ferri, Estela, BAXENDALE, Ian R, SHARLEY, James S
Format Patent
LanguageEnglish
Published 21.05.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of α-dehydroherbac and the scope is demonstrated with a small collection of additional substrates.
Bibliography:Application Number: US201816604227