Spirocyclic Indolines as IL-17 Modulators

A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

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Bibliographic Details
Main Authors Quincey, Joanna Rachel, Townsend, Robert James, Taylor, Richard David, Jones, Elizabeth Pearl, Chappell, Rose Elizabeth, Smalley, Adam Peter, Brace, Gareth Neil, Deboves, Hervé Jean Claude, Zhu, Zhaoning, Foley, Anne Marie, Foulkes, Gregory, Selby, Matthew Duncan, Lecomte, Fabien Claude, Schulze, Monika-Sarah Elisabeth Dorothea
Format Patent
LanguageEnglish
Published 07.05.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
Bibliography:Application Number: US201816619573