METHOD FOR PRODUCING RADIOHALOGEN-LABELED COMPOUND AND METHOD FOR PRODUCING RADIOPHARMACEUTICAL

Provided is a method for producing a radiohalogen-labeled compound, the method comprises: a step in which a radiohalogen-labeling precursor compound (S-L) having a leaving group (L) capable of being nucleophilically substituted by a radioactive halide ion (X−) is subjected to a radiohalogenation rea...

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Bibliographic Details
Main Authors OKUMURA, Yuki, KIRIU, Masato, TONOYA, Gota, ICHIKAWA, Hiroaki, NAKAMURA, Daisaku, SUGIMOTO, Naomi
Format Patent
LanguageEnglish
Published 23.04.2020
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided is a method for producing a radiohalogen-labeled compound, the method comprises: a step in which a radiohalogen-labeling precursor compound (S-L) having a leaving group (L) capable of being nucleophilically substituted by a radioactive halide ion (X−) is subjected to a radiohalogenation reaction to obtain a reaction mixture RM1 which contains the radiohalogen-labeling precursor compound (S-L) and a reaction product (S-X) resulting from the radiohalogenation reaction; a step in which the reaction mixture RM1 is mixed with a polyvalent acid or a salt thereof to obtain a reaction mixture RM2; and a step in which the reaction product (S-X) is purified from the reaction mixture RM2 by a solid phase extraction method.
Bibliography:Application Number: US201816625822