AMPHOTERICIN B DERIVATIVES WITH IMPROVED THERAPEUTIC INDEX

Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivativ...

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Bibliographic Details
Main Authors Davis, Stephen, Uno, Brice E, Knapp, David M, Struble, Justin, Burke, Martin D, Dailey, Ian, Gray, Kaitlyn C, Wang, Pulin, Palyam, Nagarjuna
Format Patent
LanguageEnglish
Published 02.01.2020
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
DERIVATIVES THEREOF
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
SUGARS
TRAPPING
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Summary:Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
Bibliography:Application Number: US201916530109