COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER

Methods for designing heterobifunctional small molecules which selectively degrade/disrupt CDK4/6 and compositions and methods of using such degraders/disruptors to treat CDK4/6-mediated cancer are provided.

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Bibliographic Details
Main Authors Jin, Jian, Liu, Jing, Xiong, Yan, Poulikakos, Poulikos, Yang, Xiaobao, Wu, Xuewei, Karoulia, Zoi, Ahmed, Tamer
Format Patent
LanguageEnglish
Published 07.11.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods for designing heterobifunctional small molecules which selectively degrade/disrupt CDK4/6 and compositions and methods of using such degraders/disruptors to treat CDK4/6-mediated cancer are provided.
Bibliography:Application Number: US201716467888