ENGINEERED POLYPEPTIDE CONJUGATES USING TRANSGLUTAMINASE

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods o...

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Bibliographic Details
Main Authors Farias, Santiago Esteban, Galindo Casas, Meritxell, Strop, Pavel
Format Patent
LanguageEnglish
Published 24.10.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
Bibliography:Application Number: US201816231242