CANCER TREATMENT BY GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1 INHIBITION

• Main Authors: Hai-Kun, Liu, Rusu, Patricia
• Format: Patent
• Language: English
• Published: 12.09.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to an inhibitor of glycerol-3-phosphate dehydrogenase 1 (GPD1 inhibitor) for use in treatment and/or prevention of cancer. The present invention further relates to a kit comprising a GPD1 inhibitor comprised in a housing; to a method for identifying a subject suffering from cancer susceptible to cancer treatment by administration of a GPD1 inhibitor comprising a) determining in a sample of said subject the amount of a GPD1 gene product, b) comparing said amount determined in step a) to a reference, and c) based on the result of step b), identifying a subject susceptible to cancer treatment by administration of a GPD1 inhibitor; and to further means and methods related thereto.