Thrombin-Binding Antibody Molecules And Uses Thereof

This invention relates to isolated antibodies which recognize the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin.

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Bibliographic Details
Main Authors Baglin, Trevor, Huntington, James Andrew, Langdown, Jonathan
Format Patent
LanguageEnglish
Published 12.09.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:This invention relates to isolated antibodies which recognize the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin.
Bibliography:Application Number: US201916363396