AN EX VIVO METHOD FOR TESTING CELLULAR RESPONSEIVENESS OF PRIMARY CELL POPULATIONS TO A DRUG OR COMBINATION OF DRUGS

The invention presented here relates to a method for producing an artificial environment of primary cell populations, particularly an artificial tumor environment of primary tumor cell populations and its use in an ex vivo method to test the cellular responsiveness of primary tumor cell populations...

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Main Authors ESPINOSA OQUILLAS, Ana Belén, BALLESTEROS NOBELL, Juan Antonio, PRIMO RAMOS, Daniel, PROSPERO GHIA, Paolo, HERNÁNDEZ CAMPO, Pilar, BENNETT, Teresa, GORROCHATEGUI GUILLÉN, Julián, ROBLES MATEOS, Alicia
Format Patent
LanguageEnglish
Published 11.07.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The invention presented here relates to a method for producing an artificial environment of primary cell populations, particularly an artificial tumor environment of primary tumor cell populations and its use in an ex vivo method to test the cellular responsiveness of primary tumor cell populations to a drug or drugs. The method of the invention comprises incubation of the primary tumor cells with the artificial tumor environment and the drug or drugs and analyze the response of the primary tumor cell populations. The incubation of the primary tumor cells with the artificial tumor environment, enhances the viability of said tumor cells and/or induces greater levels of tumor cell proliferation and, consequently, increases the sensitivity and accuracy of the test with regard to the drug/s assayed.
Bibliography:Application Number: US201615773400