BISPECIFIC ANTIBODIES WITH TETRAVALENCY FOR A COSTIMULATORY TNF RECEPTOR

The invention relates to novel bispecific antigen binding molecules, comprising (a) four moities capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a seco...

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Main Authors HOSSE, Ralf, GRAU-RICHARDS, Sandra, LEVITSKI, Viktor, UMANA, Pablo, AMANN, Maria, KLEIN, Christian, MOSER, Samuel, FERRARA KOLLER, Claudia, BRUENKER, Peter, CLAUS, Christina
Format Patent
LanguageEnglish
Published 11.07.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention relates to novel bispecific antigen binding molecules, comprising (a) four moities capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
Bibliography:Application Number: US201816218266