SYSTEMS AND METHODS FOR MEASUREMENT AND SEQUENCING OF BIO-MOLECULES

The present disclosure provides systems and methods for sequencing nucleic acid molecules using tunneling labels. A sequence of a nucleic acid molecule may be identified with high accuracy using a chip comprising sensors, wherein each individual sensor may comprise at least two electrodes separated...

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Main Authors NORDMAN, Eric S, GOYAL, Gaurav, KAWASAKI, Hisao, WOO, Sam, OLDHAM, Mark F, HONKURA, Toshihiko, MIHARA, Kazusuke, WOUDENBERG, Timothy M, VAKILI, Masoud
Format Patent
LanguageEnglish
Published 06.06.2019
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Summary:The present disclosure provides systems and methods for sequencing nucleic acid molecules using tunneling labels. A sequence of a nucleic acid molecule may be identified with high accuracy using a chip comprising sensors, wherein each individual sensor may comprise at least two electrodes separated by a gap. The electrodes may be configured to generate at least one electrical signal upon binding of a tunneling label associated with a nucleotide. Epigenetic information can also be determined at the same time as a nucleic acid sequence.
Bibliography:Application Number: US201816169756