Unsaturated Derivatives of Polysaccharides, Method of Preparation Thereof and Use Thereof

The invention relates to the preparation of new polysaccharide derivatives comprising a double bond in the positions 4 and 5 of the pyranose cycle. The method of preparation consists in the oxidation of OH group in the position 6 to an aldehyde, followed by the elimination to form a double -C=C- bon...

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Main Authors Vagnerova, Hana, Bobula, Tomas, Moravcikova, Sona, Basarabova, Ivana, Prochazkova, Pavlina, Sedova, Petra, Doleckova, Iva, Buffa, Radovan, Velebny, Vladimir
Format Patent
LanguageEnglish
Published 06.06.2019
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:The invention relates to the preparation of new polysaccharide derivatives comprising a double bond in the positions 4 and 5 of the pyranose cycle. The method of preparation consists in the oxidation of OH group in the position 6 to an aldehyde, followed by the elimination to form a double -C=C- bond in the positions 4 and 5, and the final reduction of the aldehyde group in the position 6 into the original alcohol. The derivatives of polysaccharides prepared according to the invention show an enhanced antioxidant activity and some of them also a selective negative influence on carcinoma cell viability. (formula) where R represents -NH-CO-CH3 or -OH.
Bibliography:Application Number: US201716311745