PROCESS FOR THE PREPARATION OF LEDIPASVIR AND INTERMEDIATES THEREOF

The present invention relates to process for preparation of ledipasvir of formula 1 and its novel intermediates. The process involves reaction of compound of formula 2 with compound of formula 3 to yield a compound of formula 4, deprotection of compound of formula 4 to yield compound of formula 5 an...

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Bibliographic Details
Main Authors Jain, Adinath Murlidhar, Agrawal, Manoj Kunjabihari, Singh, Girij Pal, Deshmukh, Swapnil Sudhakar, Godbole, Himanshu Madhav
Format Patent
LanguageEnglish
Published 28.02.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to process for preparation of ledipasvir of formula 1 and its novel intermediates. The process involves reaction of compound of formula 2 with compound of formula 3 to yield a compound of formula 4, deprotection of compound of formula 4 to yield compound of formula 5 and conversion of compound of formula 5 to Ledipasvir wherein PG is an amine protecting group provided that amino protecting group is not carbomethyloxy (-COOCH3) group; X and Y are leaving groups.
Bibliography:Application Number: US201716073606