POLYMER-BASED MATERIAL HAVING COVALENTLY BONDED ENZYMATICALLY DEGRADABLE PEPTIDE SEQUENCES

A polymer-based material having covalently bonded enzymatically degradable peptide sequences not degradable by the biological and metabolic activity of cells and tissues is disclosed, wherein the peptide sequences are incorporated into the polymer-based material or conjugated to the polymer-based ma...

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Bibliographic Details
Main Authors WERNER, CARSTEN, TEICHMANN, JULIANE, TSURKAN, MIKHAIL
Format Patent
LanguageEnglish
Published 07.02.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A polymer-based material having covalently bonded enzymatically degradable peptide sequences not degradable by the biological and metabolic activity of cells and tissues is disclosed, wherein the peptide sequences are incorporated into the polymer-based material or conjugated to the polymer-based material. The peptide sequence can be part of the three-dimensional or two-dimensional structure of the polymer-based material. A controlled degradation of a covalent bond in the peptide sequence is effected. Use of such polymer-based material for an in vitro production of cell cultures or tissues or organs, for an in vivo stabilization of donated cells, tissues or organs is also disclosed. An adhesive bond between the material and the sample, i.e. cells, tissues, or organs is controlledly degradable without destroying the integrity of the sample.
Bibliography:Application Number: US201716090965