METHOD OF PREPARING GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

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Bibliographic Details
Main Authors Gimi, Rayomand, Zhao, Jin, Siegel, Craig S, Reardon, Michael
Format Patent
LanguageEnglish
Published 31.01.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
Bibliography:Application Number: US201816051892