REGENERATED OXIDIZED CELULOSE BASED HEMOSTATIC MATERIALCONTAINING ANTIFIBROLYTIC AGENTS

In present invention oxidation method of viscon cellulose with NO2 obtained H3PO4/HNO3 is defined liquid and gas media. Regenerated oxidise cellulose (REOC in shorten term) contain in -COOH yields are standardised as 18.6-20.1 for textile, 19.8-21.5% for powder samples. Powder and textile (woven and...

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Bibliographic Details
Main Author ERTAN, Mevlut
Format Patent
LanguageEnglish
Published 18.10.2018
Subjects
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:In present invention oxidation method of viscon cellulose with NO2 obtained H3PO4/HNO3 is defined liquid and gas media. Regenerated oxidise cellulose (REOC in shorten term) contain in -COOH yields are standardised as 18.6-20.1 for textile, 19.8-21.5% for powder samples. Powder and textile (woven and fabric) products are impregnated 1.8-2.4% Ca+2 ion, 0-1.1% Na+1 ion, 0.8-1.5% tranexamic acid and 6-aminocaproic acid as antifibrinolytic. Obtained powder and gel products are impregnated Bi+3, Zn+2 and Ag+1 ions for antiseptic purposes. Only Bismuth of them is shown antibacterial effects. Also the aim of present invention is haemostat antimicrobial properties during impregnation of Rifampicin, Gatifloxacin, Doxycycline, Levofloxacin, Lincomycin, Clindamycin, Ciprofloxacin. Haemostatic properties are indicated for all products and antimicrobial properties are shown for some samples. Cytotoxicity, sensitivity and irritation properties are determined in compliance of Pharmacopeias.
Bibliography:Application Number: US201515568488