SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by alle...

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Bibliographic Details
Main Authors Koralewski, Robert, Olejniczak, Sylwia, Czestkowski, Wojciech J, Maziarz, Elzbieta, Kowalski, Michal Lukasz, Piotrowicz, Michal C, Olczak, Jacek P, Mazur, Marzena, Golebiowski, Adam A, Borek, Bartlomiej, Bartoszewicz, Agnieszka
Format Patent
LanguageEnglish
Published 13.09.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
Bibliography:Application Number: US201815908249