CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS

The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical co...

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Bibliographic Details
Main Authors HEWITT, Michael Charles, CAMPELL, John E, MA, Jianguo, MALCOLM, Scott Christopher, KOCH, Patrick, CAMPBELL, Una, ENGEL, Sharon Rae, SHAO, Liming, HARDY, Larry Wendell, VARNEY, Mark A, WANG, Fengjiang, BUSH, Larry R
Format Patent
LanguageEnglish
Published 16.08.2018
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
Bibliography:Application Number: US201715836261