Heteroaromatic Compounds and their Use as Dopamine D1 Ligands

• Main Authors: EFREMOV, IVAN VIKTOROVICH, DAVOREN, JENNIFER ELIZABETH, SUBRAMANYAM, CHAKRAPANI, GRAY, DAVID LAWRENCE FIRMAN, MENTE, SCOT RICHARD, DOUNAY, AMY BETH, NASON, DEANE MILFORD, GUILMETTE, EDWARD RAYMOND, HENDERSON, JACLYN LOUISE, ALLEN, JOHN ARTHUR, HARRIS, ANTHONY RICHARD, HELAL, CHRISTOPHER JOHN, COE, JOTHAM WADSWORTH, O'NEIL, STEVEN VICTOR, XU, WENJIAN
• Format: Patent
• Language: English
• Published: 19.07.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

and pharmaceutically acceptable salts thereof and N-oxides thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds and the uses of such compounds for the treatment of D1-mediated (or D1-associated) disorders including cognitive and motivational impairments and negative symptoms associated with illnesses such as schizophrenia, depression, bipolar disorder, Parkinson's disease, Mild cognitive impairment (MCI), Alzheimer's disease, lupus, Huntington's disease, Parkinson's, dyskinesia, ADHD, post-traumatic stress disorder, autism spectrum disorder, treatment-resistant depression, major depressive disorder (MDD), drug dependence, Tourette's syndrome, tardive dyskinesias as well as impairments associated with age, chronic stress, sleep deprivation, combat, chronic fatigue; endocrine or metabolic diseases such as hyperglycemia, dislipidemia, diabetes, obesity, and sepsis; and cardiovascular disorder such as hypertension.