Self-Supporting, Biodegradable Film Based on Hydrophobized Hyaluronic Acid, Method of Preparation and Use Thereof

• Main Authors: Minarik, Antonin, Karel, Sergej, Chmelar, Josef, Sulakova, Romana, Nesporova, Kristina, Slezingrova, Klara, Dusankova, Marcela, Huerta-Angeles, Gloria, Velebny, Vladimir
• Format: Patent
• Language: English
• Published: 19.04.2018
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR; SHAPING OR JOINING OF PLASTICS; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING; WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL; WORKING-UP

The invention relates to a self-supporting, biodegradable film comprising a C10-C22-acylated derivative of hyaluronic acid according to the general formula (I), where R is H+ or Na+, and where R1 is H or -C(=O)CxHy, where x is an integer within the range from 9 to 21 and y is an integer within the range from 11 to 43 and CxHy is a linear or branched, saturated or unsaturated C9-C21 chain, wherein in at least one repeating unit one or more of R1 is -C(=O)CxHy and where n is within the range from 12 to 4000; a method of preparation thereof and use thereof.