DIAZOLE AMIDES

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the i...

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Bibliographic Details
Main Authors CHEN Xi, FAN Pingchen, LI Yandong, PUNNA Sreenivas, DRAGOLI Dean R, JAEN Juan C, ZHANG Penglie, POWERS Jay P, MALATHONG Viengkham, TANAKA Hiroko
Format Patent
LanguageEnglish
Published 15.03.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
Bibliography:Application Number: US201715659488