OPTIMIZED ANTIBODIES THAT TARGET CD19

The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of usin...

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Bibliographic Details
Main Authors Lazar Gregory Alan, Bernett Matthew J, Desjarlais John R, Chu Seung Yup, Karki Sher Bahadur, Zhukovsky Eugene Alexander, Richards John O, Pong Erik Weiking
Format Patent
LanguageEnglish
Published 11.01.2018
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
Bibliography:Application Number: US201715712918