COOLING SYSTEMS AND METHODS FOR CRYO SUPER-RESOLUTION FLUORESCENCE LIGHT MICROSCOPY AND OTHER APPLICATIONS
New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
31.08.2017
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Subjects | |
Online Access | Get full text |
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Summary: | New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. The assembly allows for the high resolution imaging of samples at cryogenic temperatures while maintaining the temperature of the objective lens above freezing by employing circulation systems and a coupling fluid between the sample and objective lens. |
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Bibliography: | Application Number: US201715597506 |