BISPECIFIC ANTIBODIES WITH TETRAVALENCY FOR A COSTIMULATORY TNF RECEPTOR

The invention relates to novel bispecific antigen binding molecules, comprising (a) four moieties capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a sec...

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Main Authors BRUENKER PETER, FERRARA KOLLER CLAUDIA, LEVITSKI VIKTOR, GRAU-RICHARDS SANDRA, KLEIN CHRISTIAN, UMANA PABLO, AMANN MARIA, MOSER SAMUEL, CLAUS CHRISTINA, HOSSE RALF
Format Patent
LanguageEnglish
Published 31.08.2017
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The invention relates to novel bispecific antigen binding molecules, comprising (a) four moieties capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
AbstractList The invention relates to novel bispecific antigen binding molecules, comprising (a) four moieties capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
Author BRUENKER PETER
GRAU-RICHARDS SANDRA
LEVITSKI VIKTOR
CLAUS CHRISTINA
UMANA PABLO
AMANN MARIA
MOSER SAMUEL
FERRARA KOLLER CLAUDIA
KLEIN CHRISTIAN
HOSSE RALF
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– fullname: KLEIN CHRISTIAN
– fullname: UMANA PABLO
– fullname: AMANN MARIA
– fullname: MOSER SAMUEL
– fullname: CLAUS CHRISTINA
– fullname: HOSSE RALF
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Snippet The invention relates to novel bispecific antigen binding molecules, comprising (a) four moieties capable of specific binding to a costimulatory TNF receptor...
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SubjectTerms CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title BISPECIFIC ANTIBODIES WITH TETRAVALENCY FOR A COSTIMULATORY TNF RECEPTOR
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