ANTI-IL-1beta ANTIBODIES AND METHODS OF USE

Herein are reported humanized anti-IL-1beta antibodies that are humanized variants of the murine anti-IL-1beta antibody H34. A specific humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 27, and...

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Main Authors Huelsmann Peter Michael, Breuer Sebastian, Gassner Christian, Schumacher Ralf, Gruener Sabine, Mundigl Olaf, Georges Guy, Hartmann Guido, Dengl Stefan
Format Patent
LanguageEnglish
Published 31.08.2017
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Herein are reported humanized anti-IL-1beta antibodies that are humanized variants of the murine anti-IL-1beta antibody H34. A specific humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 27, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 28.
Bibliography:Application Number: US201715590161