PYRIDINE DERIVATIVE

As a result, the inventors have found that (2R)-3-amino-2-{[4-(substituted pyridine)-2-yl]methyl}-2-hydroxy-propanoic acid derivatives have excellent P-LAP inhibitory activity. The inventors have evaluated antidiuretic effects in water-loaded rats and have found that the compounds increase endogenou...

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Bibliographic Details
Main Authors TSUCHIYA Kazuyuki, HANADATE Tadaatsu, KAWAGUCHI Kenichi, KANAI Akira, ENJO Kentaro, ISHIHATA Akihiro, MORIKAWA Hiroshi, INAGAKI Yusuke, KAZAMI Junichi, HIRAMOTO Masashi, KAIZAWA Hiroyuki, TAKAMATSU Hajime
Format Patent
LanguageEnglish
Published 06.07.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:As a result, the inventors have found that (2R)-3-amino-2-{[4-(substituted pyridine)-2-yl]methyl}-2-hydroxy-propanoic acid derivatives have excellent P-LAP inhibitory activity. The inventors have evaluated antidiuretic effects in water-loaded rats and have found that the compounds increase endogenous AVP levels by inhibiting P-LAP and consequently reduce urine production. The present invention therefore provides compounds expected to be used as an agent for treating nocturia based on P-LAP inhibition.
Bibliography:Application Number: US201515313712