Method for Storing an Emulsion-Adjuvanted Vaccine in a Lubricated Medical Injection Device

• Main Authors: Bonhoure Fabien, Bralet Nicolas, Hamel Jean-Bernard, Jouffray Sébastien
• Format: Patent
• Language: English
• Published: 29.06.2017
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; CONVEYING; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FUELS; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; LUBRICANTS; LUBRICATING COMPOSITIONS; MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PACKING; PEAT; PERFORMING OPERATIONS; PETROLEUM, GAS OR COKE INDUSTRIES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; STORING; TECHNICAL GASES CONTAINING CARBON MONOXIDE; TRANSPORTING; UNPACKING; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATINGINGREDIENTS IN A LUBRICATING COMPOSITION

Provided herein is a method for storing an emulsion-adjuvanted vaccine in a medical injection device having a lubricant coating, said method including the steps of: (a) providing a medical injection device having a barrel having an inner surface; (b) forming a silicone oil layer on at least a part of the inner surface of the barrel that is intended to be in contact with the vaccine; (c) carrying out an oxidizing plasma treatment of the layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating; and (d) filling the barrel with the emulsion-adjuvanted vaccine. The invention also relates to a medical injection device obtained directly from this method and to the use of plasma-treated silicone oil as a lubricant coating.